Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer.

ABSTRACT: Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attractive therapeutic targets. However, the mechanisms regulating TLS formation and maintenance in cancer are incompletely understood. Using spatial transcriptomics and multiplex imaging across various human tumors, we found an enrichment of mature dendritic cells (DC) expressing high levels of CCR7 in TLS, prompting us to investigate the role of DC in the formation and maintenance of TLS in solid tumors. To address this, we developed a novel murine model of non-small cell lung cancer (NSCLC) that forms mature TLS, containing B cell follicles with germinal c

SUBMITTER: Mattiuz R 

PROVIDER: S-EPMC11703156 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature