An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.

ABSTRACT: Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions¹. We have expanded the Registry to include 2.35 million human and 927 thousand mouse cCREs, leveraging new ENCODE datasets and enhanced computational methods. This expanded Registry covers hundreds of unique cell and tissue types, providing a comprehensive understanding of gene regulation. Functional characterization data from assays like STARR-seq, MPRA, CRISPR perturbation, and transgenic mouse assays now c

SUBMITTER: Moore JE 

PROVIDER: S-EPMC11703161 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature