Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.

ABSTRACT:

Background

Juxtaglomerular (JG) cells are sensors that control blood pressure (BP) and fluid-electrolyte homeostasis. They are arranged as clusters at the tip of each afferent arteriole. In response to a decrease in BP or extracellular fluid volume, JG cells secrete renin, initiating an enzymatic cascade that culminates in the production of angiotensin II (AngII), a potent vasoconstrictor that restores BP and fluid-electrolyte homeostasis. In turn, AngII exerts negative feedback on renin release concomitantly with increased intracellular Ca²⁺, preventing excessive circulating renin and hypertension. However, within their native structural organization, the intricacies of intracellular Ca²⁺ signaling dynamics and their sources remain uncharacterized.

Methods

SUBMITTER: Yamaguchi H 

PROVIDER: S-EPMC11703171 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature