Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.

ABSTRACT: Over the past two decades, rapid advancements in magnetic resonance technology have significantly enhanced the imaging resolution of functional Magnetic Resonance Imaging (fMRI), far surpassing its initial capabilities. Beyond mapping brain functional architecture at unprecedented scales, high-spatial-resolution acquisitions have also inspired and enabled several novel analytical strategies that can potentially improve the sensitivity and neuronal specificity of fMRI. With small voxels, one can sample from different levels of the vascular hierarchy within the cerebral cortex and resolve the temporal progression of hemodynamic changes from parenchymal to pial vessels. We propose that this characteristic pattern of temporal progression across cortical depths can aid in distinguishing neuroge

SUBMITTER: Chen JE 

PROVIDER: S-EPMC11703183 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature