The RNA-binding protein HuR impairs adipose tissue anabolism in pancreatic cancer cachexia.

ABSTRACT:

Background

Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC), and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear. This work aims to define the relative contributions of catabolism and anabolism to adipose wasting in PDAC-bearing mice. Human antigen R (HuR) is an RNA-binding protein recently shown to suppress adipogenesis. We hypothesize that fat wasting results from a loss of adipose anabolism driven by increased HuR activity in adipocytes of PDAC-bearing mice.

Methods

Adult C57BL/6J mice received orthotopic PDAC cell (Kras ^G12D ; p53 ^R172H/+

SUBMITTER: Arneson-Wissink PC 

PROVIDER: S-EPMC11703191 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature