Novel interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression.

ABSTRACT: Organisms with smaller genomes often perform multiple functions using one multi-subunit protein complex. The S. cerevisiae Silent Information Regulator complex (SIRc) carries out all of the core functions of heterochromatin. SIR complexes first drive the initiation and spreading of histone deacetylation in an iterative manner. Subsequently, the same complexes are incorporated stably with nucleosomes, driving compaction and repression of the underlying chromatin domain. These two distinct functions of SIRc have each been characterized in much detail, but the mechanism by which the dynamic spreading state switches to stable compaction is not well-understood. This incomplete knowledge of potential intra-complex communication is partly due to a lack of structural information of the comp

SUBMITTER: Kotz J 

PROVIDER: S-EPMC11703230 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature