Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice.

ABSTRACT: Maternal stress during pregnancy, or prenatal stress, is a risk factor for neurodevelopmental disorders in offspring, including autism spectrum disorder (ASD). In ASD, dorsal striatum displays abnormalities correlating with symptom severity, but there is a gap in knowledge about dorsal striatal cellular and molecular mechanisms that may contribute. Using a mouse model, we investigated how prenatal stress impacted striatal-dependent behavior in adult offspring. We observed enhanced motor learning and earlier response times on an interval timing task, with accompanying changes in time-related medium spiny neuron (MSN) activity. We performed adult dorsal striatal single-cell RNA sequencing following prenatal stress which revealed differentially expressed genes (DEGs) in multiple cell types; d

SUBMITTER: Evans MM 

PROVIDER: S-EPMC11703269 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature