Asynchronous Transitions from Hepatoblastoma to Carcinoma in High-Risk Pediatric Tumors.

ABSTRACT: Most malignant hepatocellular tumors in children are classified as either hepatoblastoma (HB) or hepatocellular carcinoma (HCC), but some tumors demonstrate features of both HB and HCC^1-3. These tumors have been recognized under a provisional diagnostic category by the World Health Organization and are distinguished from HB and HCC by a combination of histological, immunohistochemical, and molecular features^4-6. Their outcomes and cellular composition remain an open question^7-9. The heterogeneous histological and molecular profiles of hepatoblastomas with carcinoma features (HBCs)⁴ may result from cells with combined HB and HCC characteristics (HBC cells) or from mixtures of cells displaying either HB or HCC signatures. We used multiomics profili

SUBMITTER: Yu X 

PROVIDER: S-EPMC11703271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature