Common and rare genetic variation intersects with ancestry to influence human skin and plasma carotenoid concentrations.

ABSTRACT: Carotenoids are dietary bioactive compounds with health effects that are biomarkers of fruit and vegetable intake. Here, we examine genetic associations with plasma and skin carotenoid concentrations in two rigorously phenotyped human cohorts (n=317). Analysis of genome-wide SNPs revealed heritability to vary by genetic ancestry (h²=0.08-0.44) with ten SNPs at four loci reaching genome-wide significance (P<5E-08) in multivariate models, including at RAPGEF1 (rs3765544, P=8.86E-10, beta=0.75) with α-carotene, and near IGSF11 (rs80316816, P=6.25E-10, beta=0.74), with cryptoxanthin; these were replicated in the second cohort (n=110). Multiple SNPs near IGSF11 demonstrated genotype-dependent dietary effects on plasma cryptoxanthin. Deep sequencing of 35 candidat

SUBMITTER: Han Y 

PROVIDER: S-EPMC11703293 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature