Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis.

ABSTRACT:

Objective

Advancing the understanding of the pathophysiology of eosinophilic oesophagitis (EoE) and other eosinophilic gastrointestinal diseases (EGIDs) has spurred research into targeted biological therapies, while the conclusive therapeutic efficacy of biologics remains uncertain. In this review, we conducted a meta-analysis of all RCTS of biologics in the treatment of EoE to evaluate their efficacy and safety and discussed their treatment of non-EoE EGIDs.

Methods

We searched the PubMed, EMBASE, Cochrane Library, and Web of Science databases. Double-blind randomized controlled trials comparing biologics with placebo in patients with EoE and non-EoE EGIDs were collected and further screened for inclusion and exclusion. The caliber of the included literature was evaluated u

SUBMITTER: Zeng B 

PROVIDER: S-EPMC11703371 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature