Estimated clinical utility of multi-gene pharmacogenetic testing in a retrospective cohort of gynecology patients.

ABSTRACT:

Objective

This study aimed to estimate the clinical utility of performing multi-gene pharmacogenetic testing on patients undergoing gynecologic surgery/procedure by evaluating the prescribing rate of Clinical Pharmacogenetics Implementation Consortium (CPIC) level A medications and frequency of drug-gene interactions (DGIs).

Methods

The electronic health record was queried for 76 current procedural terminology codes to identify gynecologic surgeries/procedures that occurred between 1 January 2015 to 31 December 2020 in patients with at least one of 152 international classification of disease codes. Prescription data for CPIC level A medications was extracted. Those enrolled in the Penn Medicine Biobank were assessed for DGIs.

Results

The cohort consisted of 7798 femal

SUBMITTER: Hoffecker G 

PROVIDER: S-EPMC11703490 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature