Ultrasmall solid lipid nanoparticles as a potential innovative delivery system for a drug combination against glioma.

ABSTRACT:

Introduction

High grade gliomas are characterized by a very poor prognosis due to fatal relapses after surgery. Current chemotherapy is only a palliative care, while potential drug candidates are limited by poor overcoming of the blood-brain barrier.

Aims

A suitable chemotherapeutic approach should be engineered to overcome both the altered blood-brain barrier in the glioma site, as well as the intact one in the brain adjacent to tumor zone, and to target the multiple factors influencing glioma proliferation, differentiation, migration, and angiogenesis.

Materials & methods

In this experimental research, ultrasmall solid lipid nanoparticles were prepared owing to the temperature phase inversion technology and loaded with a specific drug combination made of paclitaxel,

SUBMITTER: Battaglia L 

PROVIDER: S-EPMC11703491 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature