Bioinspired caffeic acid-laden milk protein-based nanoparticles targeting folate receptors for breast cancer treatment.

ABSTRACT:

Aims

Breast cancer is the second leading cause of death worldwide. Conventional chemotherapeutic therapies lack the specific targeting effect toward the cancerous cells resulting in extensive side effects. Our current study endeavors to prepare novel bioinspired folic acid-functionalized caffeic acid (CA)-loaded casein nanoparticles (CS NPs) for curbing breast cancer.

Methods

CA-CS NPs were prepared by simple coacervation method followed by lyophilization. Functionalized CS NPs were achieved using folic acid as the targeting moiety. Entire comparative characterization between unconjugated and conjugated NPs were implemented in terms of size, polydispersity index, surface charge, ¹H-NMR, surface morphology, in-vitro drug release, sterilization, cytotoxicity,

SUBMITTER: Safwat S 

PROVIDER: S-EPMC11703524 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature