Identification of ALDH7A1 as a DNA-methylation-driven gene in lung squamous cell carcinoma.

ABSTRACT:

Background

Deoxyribose nucleic acid (DNA) methylation is an important epigenetic modification that plays an important role in the occurrence and development of tumors. Identifying key methylation-driven genes that affect the prognosis of lung squamous cell carcinoma (LUSC) can provide direction for targeted therapy research.

Methods and results

Methylation and RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA). The MethylMix package was used to integrate and analyze the methylation and gene expression data from TCGA, and the LUSC dataset (GSE37745) was downloaded from GEO for validation. Forty-five DNA-methylation-driven genes (MDGs) were obtained, and 3 genes (TRIM61, SMIM22, and ALDH7A1) were significantly associated with survival by using univariate and mult

SUBMITTER: Liang G 

PROVIDER: S-EPMC11703541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature