Paraneoplastic Neurologic Syndrome Associated with Fallopian Tube Cancer: A Case Report.

ABSTRACT:

Introduction

Paraneoplastic neurological syndrome (PNS) was identified as a rare and unique clinical complication of primary tumors. Paraneoplastic cerebellar degeneration, a subtype of PNS, involved an immune-mediated attack on cerebellar Purkinje cells, resulting in a series of cerebellar symptoms.

Case presentation

We report a case of an elderly female patient who presented with subacute cerebellar symptoms, positive anti-YO antibody, and elevated CA-125 levels. Further examination revealed a fallopian tube malignancy. After surgery, intravenous immunoglobulin and glucocorticoid treatment, the oncological response was satisfactory, but the neurological symptoms did not improve.

Conclusion

This case illustrates the importance of considering a paraneoplastic etiology

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11703544 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature