Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis.

ABSTRACT:

Background

Mitochondrial dysfunction and damage can result in the release of mitochondrial DNA (mtDNA) into the cytoplasm, which subsequently activates the cGAS-STING pathway, promoting the onset of inflammatory diseases. Various factors, such as oxidative stress, viral infection, and drug toxicity, have been identified as inducers of mitochondrial damage. This study aims to investigate the role of mtDNA as a critical inflammatory mediator in the pathogenesis of ketamine (KET)-induced cystitis (KC) through the cGAS-STING pathway.

Methods

To investigate the role of the cGAS-STING pathway in KET-induced cystitis, we assessed the expression of cGAS and STING in rats with KET cystitis. Additionally, we evaluated STING expression in conditionally deficient Simian Virus-transforme

SUBMITTER: Chen J 

PROVIDER: S-EPMC11703929 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature