A universal gene expression signature-based strategy for the high-throughput discovery of anti-inflammatory drugs.

ABSTRACT:

Background

Traditional Chinese medicine (TCM) is a valuable resource for drug discovery and has demonstrated excellent efficacy in treating inflammatory diseases. This study aimed to develop a universal gene signature-based strategy for high-throughput discovery of anti-inflammatory drugs, especially Traditional Chinese medicine (TCM).

Methods

The disease gene signature of liposaccharide-stimulated THP-1 cells and drug gene signatures of 655 drug candidates were established via sequencing. Anti-inflammatory drugs were screened based on similarities between drug gene signatures and the reversed disease gene signature.

Results

Through screening, 83 potential anti-inflammatory drugs were identified. The efficacy of the TCM formula Biyun Powder, along with individual TCMs

SUBMITTER: Feng J 

PROVIDER: S-EPMC11703948 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature