The Efficacy of Botulinum Toxin A Injection in Pelvic Floor Muscles in Chronic Pelvic Pain Patients: A Double-Blinded Randomised Controlled Trial.

ABSTRACT:

Objective

To evaluate and compare the efficacy and safety of Botulinum Toxin A (BTA) injections versus placebo injections, combined with pelvic floor muscle therapy (PFMT), in women with chronic pelvic pain (CPP).

Design

Randomised, double-blinded clinical trial (January 2020-April 2023).

Setting

This multicentre study was conducted at four hospitals in the Netherlands.

Population and sample

Ninety-four women with CPP and increased pelvic floor muscle tone despite previous PFMT, were enrolled.

Methods

Participants received either BTA injections (100 units) or placebo injections into the pelvic floor muscle, followed by four PFMT sessions.

Main outcomes and measures

Primary outcomes included the number of women with at least a 33% reduction in pain

SUBMITTER: Spruijt MA 

PROVIDER: S-EPMC11704059 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature