Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study.

ABSTRACT:

Purpose

Androgen signaling is associated with various secondary cancer, which could be promising for potential treatment using androgen deprivation therapy (ADT). This study investigated whether ADT use was associated with secondary cancers other than prostate cancer in a nationwide population-based cohort.

Materials and methods

A total, 278,434 men with newly diagnosed prostate cancer between January 1, 2002 and December 31, 2017 were identified. After applying the exclusion criteria, 170,416 men were enrolled. The study cohort was divided into ADT and non-ADT groups by individual matching followed by propensity score matching (PSM). Study outcomes were incidence of all male cancers. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs

SUBMITTER: Kim JH 

PROVIDER: S-EPMC11704168 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature