Access to fluorinated dienes through hydrofluorination of 2-En-4-ynoates.

ABSTRACT: The hydrofluorination of enynoates has been developed for the synthesis of fluorinated dienoates. Using a pyridinium tetrafluoroborate salt that is easily prepared on large scale, this approach enabled the direct conversion of these substrates to fluorinated targets through a vinyl cation mediated process. This approach was applied to a range of aryl-substituted enynoates to deliver the (Z)-configured products with high levels of stereo- and regioselectivity. Mechanistic studies were conducted to provide insights into the stereochemical outcome and reaction efficiency under different reaction conditions.

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11704660 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature