Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy - a randomized controlled trial.

ABSTRACT:

Background

Electrotherapy has been investigated in chronic pain and diabetic peripheral neuropathy, however prospective trials in patients with chemotherapy-induced peripheral neuropathy (CIPN) are scarce.

Methods

Fifty-one patients with CIPN ≥ grade 1 subsequent to receiving platinum- and/or taxane-based chemotherapy types were randomized to 8 weeks of high tone external muscle stimulation (HTEMS) or transcutaneous electrical nerve stimulation (TENS). The primary outcome were changes in the EORTC-QLQ-CIPN20 questionnaire. Secondary outcomes included clinical examinations, a classification of CIPN according to CTCAE v 4 and the EORTC-QLQ-C30 questionnaire. A control group (n = 17) receiving no intervention was recruited retrospectively.

Results

The EORTC-QLQ-CIPN20 se

SUBMITTER: Sassmann R 

PROVIDER: S-EPMC11704885 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature