Single-cell analysis unveils cell subtypes of acral melanoma cells at the early and late differentiation stages.

ABSTRACT:

Background

Melanoma, a malignant neoplasm originating from melanocytes, is a form of skin cancer with rapidly increasing global incidence, often exacerbated by UV radiation[1]. Particularly, acral melanoma, characterized by its swift metastasis and poor prognosis, underscores the significance of further research into its heterogeneity. Single-cell sequencing has been widely utilized in the study of tumor heterogeneity; however, research related to melanoma remains to be further refined.

Materials and methods

We employed single-cell RNA sequencing (scRNA-seq) transcriptomic analysis to delve into the melanoma cells from six samples of melanoma patients. This approach enabled the identification of critical melanoma cell subpopulations and their roles in melanoma progression. S

SUBMITTER: Hou M 

PROVIDER: S-EPMC11705046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature