Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.

ABSTRACT: Long-term memory (LTM) formation relies on de novo protein synthesis; however, the full complement of proteins crucial to LTM formation remains unknown in any system. Using an aversive operant conditioning model of aerial respiratory behavior in the pond snail mollusk, Lymnaea stagnalis (L. stagnalis), we conducted a transcriptome-guided proteomic analysis on the central nervous system (CNS) of LTM, no LTM, and control animals. We identified 366 differentially expressed proteins linked to LTM formation, with 88 upregulated and 36 downregulated in LTM compared to both no LTM and controls. Functional annotation highlighted the importance of balancing protein synthesis and degradation for LTM, as indicated by the upregulation of proteins involved in proteasome activity an

SUBMITTER: Bandura J 

PROVIDER: S-EPMC11705228 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature