Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome.

ABSTRACT: Working memory (WM) plays a crucial role in human cognition. Previous candidate and genome-wide association studies have reported many genetic variations associated with WM. However, little research has examined genetic basis of WM by using transcriptome, even though it reflects gene function more directly than does the genome. Here we propose a new approach to exploring the genetic mechanisms of WM by integrating connectome, transcriptome, and genome data in a high-quality dataset comprising 481 Chinese healthy adults. First, relevance vector regression was used to define WM-related brain regions. Second, genes differentially expressed within these regions were identified using the Allen Human Brain Atlas (AHBA) dataset. Finally, two independent datasets were used to validate these genes'

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11705410 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature