The Protective Role of Ambient Ultraviolet Radiation Against Dementia: An Ecological Analysis of Global Data.

ABSTRACT:

Background and aims

This study investigates the global impact of ambient ultraviolet radiation (UVR) on dementia incidence, addressing its controversial association with dementia risk. UVR, through both vitamin D-dependent and independent mechanisms, influences physiological processes essential for brain health, such as reducing neuroinflammation, improving sleep regulation, and enhancing neuroplasticity. This study aims to clarify the relationship between UVR and dementia incidence and evaluate its role in public health strategies for dementia prevention.

Methods

An ecological analysis across 204 countries was conducted using country-specific data on UVR levels and dementia incidence rates. Bivariate analysis, partial correlation, and multiple linear regression models were

SUBMITTER: You W 

PROVIDER: S-EPMC11705424 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature