Relationship between chlorhexidine gluconate concentration and microbial colonization of patients' skin.

ABSTRACT:

Objective

To characterize the relationship between chlorhexidine gluconate (CHG) skin concentration and skin microbial colonization.

Design

Serial cross-sectional study.

Setting/participants

Adult patients in medical intensive care units (ICUs) from 7 hospitals; from 1 hospital, additional patients colonized with carbapenemase-producing Enterobacterales (CPE) from both ICU and non-ICU settings. All hospitals performed routine CHG bathing in the ICU.

Methods

Skin swab samples were collected from adjacent areas of the neck, axilla, and inguinal region for microbial culture and CHG skin concentration measurement using a semiquantitative colorimetric assay. We used linear mixed effects multilevel models to analyze the relationship between CHG concentration and micr

SUBMITTER: Rhee Y 

PROVIDER: S-EPMC11705612 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature