Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms.

ABSTRACT: Autophagy is essential for maintaining material balance and energy circulation and plays a critical role as a regulatory mechanism in tissue regeneration. However, current studies primarily describe this phenotype, with limited exploration of its molecular mechanisms. In this study, we provided the first evidence that autophagy is required for intestinal regeneration in Apostichopus japonicus and identified a previously unrecognized regulatory mechanism involved in this process. We observed that autophagy activation was significantly associated with enhanced regeneration, and its upregulation was shown to be regulated by reactive oxygen species (ROS) bursts. Mechanistically, ROS induced the dephosphorylation of Forkhead box protein O (FoxO) through AjAKT dephosphorylation. The dephosphoryl

SUBMITTER: Zeng C 

PROVIDER: S-EPMC11705696 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature