Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.

ABSTRACT: The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like Candida albicans, Exophiala spinifera, and Malassezia restricta, with Exophiala and Malassezia showing the most significant changes (Wilcoxon rank-sum test, P < 0.001, fold change >10). Network analysis revealed a less interconnected and more uneven gut microbial network in ACVD patients. Ne

SUBMITTER: Su G 

PROVIDER: S-EPMC11705818 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature