Functional significance of some common oxytocin receptor SNPs involved in complex human traits.

ABSTRACT:

Background

Oxytocin function is associated with a range of human traits and is often indexed by common polymorphisms of the receptor gene OXTR. Little is known however about the functional significance of these polymorphisms.

Objectives

To examine the effects of common polymorphisms of OXTR on transcription expression in human neural cells.

Method

The impact of four common OXTR SNPs (rs1042778, rs4686302, rs2254298 and rs237887) on OXTR gene expression were tested in human neuroblastoma cell line, SH-SY5Y, a commonly used cell line for neurological disease. SNPs were chosen as having robust evidence for associations with complex human traits after consideration of linkage patterns across OXTR.

Results

The expression level of GG genotype of rs1042778 was signifi

SUBMITTER: Ma SL 

PROVIDER: S-EPMC11705901 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature