The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty.

ABSTRACT:

Background

Increasing evidence shows that postoperative innate immune dysregulation is associated with delayed recovery and infectious complications. The aim of this study was to compare the effects of general versus spinal anesthesia on innate immune function during and after total hip arthroplasty (THA).

Methods

This comparative matched cohort study used data from two single-center randomized-controlled trials. Patients from the control group of the HIPPO study received general anesthesia and were matched to control patients from the MAGIC study who received spinal anesthesia in a 2:1 ratio (general(n = 18); spinal(n = 9)). Immune function was assessed by determination of ex vivo cytokine production capacity upon whole blood stimulation with E. coli lipopolysaccharides (LP

SUBMITTER: Jacobs LMC 

PROVIDER: S-EPMC11705907 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature