Mode of action of silver-based perovskite against Gram-negative bacteria.

ABSTRACT: Although silver is known for its antibacterial activity, its exact mode of action remains unclear. In our previous work, we described AgNbO₃ nanoparticles (AgNbO₃ NPs) prepared using a ceramic method, followed by high-energy and low-energy ball-milling processes, which exhibited antimicrobial activity with negligible release of Ag⁺ in deionized water. Here, we investigated thoroughly the mode of action of these AgNbO₃ NPs against Escherichia coli. Drastic morphological changes in E. coli were observed after their exposure to AgNbO₃ NPs. In addition to cellular damage, AgNbO₃ NPs induced the production of reactive oxygen species and lipid peroxidation, likely following the release of small amounts of Ag⁺

SUBMITTER: Fani F 

PROVIDER: S-EPMC11705935 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature