Reversal gene expression assessment for drug repurposing, a case study of glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is a rare brain cancer with an exceptionally high mortality rate, which illustrates the pressing demand for more effective therapeutic options. Despite considerable research efforts on GBM, its underlying biological mechanisms remain unclear. Furthermore, none of the United States Food and Drug Administration (FDA) approved drugs used for GBM deliver satisfactory survival improvement.

Methods

This study presents a novel computational pipeline by utilizing gene expression data analysis for GBM for drug repurposing to address the challenges in rare disease drug development, particularly focusing on GBM. The GBM Gene Expression Profile (GGEP) was constructed with multi-omics data to identify drugs with reversal gene expression to GGEP from the Inte

SUBMITTER: Sun S 

PROVIDER: S-EPMC11706105 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature