Signaling via retinoic acid receptors mediates decidual angiogenesis in mice and human stromal cell decidualization.

ABSTRACT: At the maternal-fetal interface, tightly regulated levels of retinoic acid (RA), the physiologically active metabolite of vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human cells, and pharmacological tools to demonstrate how depletion of RA signaling via RA receptor (RAR) disrupts implantation and progression of early pregnancy. To inhibit RAR signaling during early pregnancy, BMS493, an inverse pan-RAR agonist that prevents RA-induced differentiation, was administered to pregnant mice during the peri-implantation period. Attenuation of RA/RAR signaling prior to embryo implantation results in implantation failure, whereas attenuation of RA/RAR signaling after embryo implantation disrupts the post-implantation decidual vascu

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11706222 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature