Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study.

ABSTRACT: Population-based cohort studies are essential for understanding the pathological basis of dementia in older populations. Previous studies have shown that limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) increases with age, but there have been only a few studies, which have investigated this entity in a population-based setting. Here we studied the frequency of LATE-NC and its associations with other brain pathologies and cognition in a population aged ≥ 85 years. The population-based Vantaa 85+ study cohort includes all 601 individuals aged ≥85 years who were living in Vantaa, Finland in 1991. A neuropathological examination was performed on 304 subjects (50.5%) and LATE-NC staging was possible in 295 of those. Dementia status and Mini-Mental State Exam

SUBMITTER: Mikhailenko E 

PROVIDER: S-EPMC11706281 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature