Drosulfakinin signaling encodes early-life memory for adaptive social plasticity.

ABSTRACT: Drosophila establishes social clusters in groups, yet the underlying principles remain poorly understood. Here, we performed a systemic analysis of social network behavior (SNB) that quantifies individual social distance (SD) in a group over time. The SNB assessment in 175 inbred strains from the Drosophila Genetics Reference Panel showed a tight association of short SD with long developmental time, low food intake, and hypoactivity. The developmental inferiority in short-SD individuals was compensated by their group culturing. By contrast, developmental isolation silenced the beneficial effects of social interactions in adults and blunted the plasticity of SNB under physiological challenges. Transcriptome analyses revealed genetic diversity for SD traits, whereas social isol

SUBMITTER: Jeong J 

PROVIDER: S-EPMC11706606 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature