Tianeptine Exposures Reported to United States Poison Centers, 2015-2023.

ABSTRACT:

Introduction

Tianeptine is an atypical tricyclic antidepressant not approved for medical use in the US but is found in dietary supplements. This study investigates single-substance tianeptine exposures reported to US poison centers.

Methods

We analyzed cases involving tianeptine reported to the National Poison Data System from 2015 to 2023.

Results

There were 892 single-substance tianeptine exposures reported to US poison centers from 2015 to 2023, and the rate of exposures increased 1,400% from 2015 to 2023, including a 525% increase from 2018 to 2023. Most exposures were associated with moderate (51.5%) or major (12.0%) effects, and 40.1% required medical admission, including 22.9% to a critical care unit. Individuals 50 years and older were more likely to experienc

SUBMITTER: Quadir M 

PROVIDER: S-EPMC11706824 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature