Spinal cord gray matter atrophy is associated with disability in spinal muscular atrophy.

ABSTRACT:

Background

With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need for biomarkers for disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation and quantification in vivo. This study aims to assess SC GM atrophy in patients with 5q-SMA and its associations with clinical disability.

Methods

Twenty-one patients with 5q-SMA and twenty-one age- and sex-matched healthy controls (HCs) prospectively underwent 3 T axial 2D-rAMIRA MR-imaging at the intervertebral disc levels C2/C3-C5/C6 and T_max (lumbar enlargement level). Associations between SC GM areas with muscle strength

SUBMITTER: Kesenheimer EM 

PROVIDER: S-EPMC11706851 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature