Factors behind poor cognitive outcome following a thalamic stroke.

ABSTRACT:

Background

Thalamic strokes produce neurological, cognitive, and behavioral symptoms depending on the thalamic nuclei involved. While traditionally associated with severe cognitive deficits, recent studies suggest more modest impairments. This study aims to identify the factors that influence the severity of cognitive impairment following thalamic stroke.

Methods

We recruited 40 patients (mean age 51.1) with chronic isolated thalamic stroke and 45 healthy subjects (mean age 48.5) who underwent neuroimaging and neuropsychological assessment. Cluster and principal component analyses were used to discriminate patients from healthy subjects based on cognitive tasks. Disconnectome maps and cortical thickness were analyzed to understand the distant impact of thalamic strokes.

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SUBMITTER: Vidal JPC 

PROVIDER: S-EPMC11706879 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature