QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep.

ABSTRACT: Since the early discovery of QRFP43, intensive research has been primarily focused on its role in the modulation of food intake. As is widely recognised, the regulation of the body's energy status is a highly complex process involving numerous systems, hormones and neurotransmitters. Among the most important regulators of energy status, alongside the satiety and hunger centre located in the hypothalamus, is the HPT axis, which directly and indirectly affects the regulation of metabolism in all cells of the body. Therefore, it seems highly important to conduct studies aimed at elucidating how QRFP43 may impact the secretory activity of the HPT axis. The objective of this work was to investigate the role of QRFP43 in modulating HPT axis activity in sheep. The study examined mRNA and peptide

SUBMITTER: Przybyl BJ 

PROVIDER: S-EPMC11707026 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature