Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition.

ABSTRACT: Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions. Survivors often suffer lasting neurocognitive consequences that impact academic performance and socioeconomic outcomes. Mechanistic understanding of the emergence of these consequences is poorly understood. Using multi-system SHAP interpreted random forest models and network analysis, we show that Moderate Acute Malnutrition (MAM) associates with enrichment of faecal Rothia mucilaginosa, Streptococcus salivarius and depletion of Bacteroides fragilis in a cohort of one-year-old children in Dhaka, Bangladesh. These microbiome changes form interconnected pathways that involve reduced plasma odd-chain fatty acid levels, decreased gamma and beta electroencephalogram power in temporal an

SUBMITTER: Portlock T 

PROVIDER: S-EPMC11707170 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature