Contraceptives or Hormone Replacement Therapy and Associations with Autoimmune Conditions: Exploring Effects of Estrogen Analog Supplementation.

ABSTRACT:

Objective

The aim of this study was to investigate the impact of estrogen and progesterone analog supplementation on the development of autoimmune conditions.

Methods

This retrospective observational study used data from the TriNetX network, which comprised over 100 million patients from 89 health care organizations. We compared patients exposed to estrogen and progesterone analogs to those exposed to progesterone-only therapy, using 1:1 propensity score matching based on age, ethnicity, and additional criteria. The primary outcomes were incidences of various autoimmune conditions.

Results

We included 3,338,925 patients in the group who received estrogen and progesterone and 2,090,758 patients in the group who received progesterone only. Prematching, the group who rec

SUBMITTER: Tskhakaia I 

PROVIDER: S-EPMC11707263 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature