Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.

ABSTRACT:

Background

Understanding factors associated with antimicrobial resistance (AMR) distribution across populations is a necessary step in planning mitigation measures. While associations between AMR and socioeconomic-status (SES), including employment and education have been increasingly recognized in low- and middle-income settings, connections are less clear in high-income countries where SES remains an important influence on other health outcomes.

Methods

We explored the relationship between SES and AMR in Calgary, Canada using spatially-resolved wastewater-based surveillance of resistomes detected by metagenomics across eight socio-economically diverse urban neighborhoods. Resistomes were established by shotgun-sequencing of wastewater pellets, and qPCR of targeted-AMR gene

SUBMITTER: Lee J 

PROVIDER: S-EPMC11707339 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature