LncRNA <i>CARINH</i> regulates expression and function of innate immune transcription factor IRF1 in macrophages.

ABSTRACT: The discovery of long non-coding RNAs (lncRNAs) has provided a new perspective on the centrality of RNA in gene regulation and genome organization. Here, we screened for lncRNAs with putative functions in the host response to single-stranded RNA respiratory viruses. We identify CARINH as a conserved cis-acting lncRNA up-regulated in three respiratory diseases to control the expression of its antisense gene IRF1, a key transcriptional regulator of the antiviral response. CARINH and IRF1 are coordinately increased in the circulation of patients infected with human metapneumovirus, influenza A virus, or SARS-CoV-2, and in macrophages in response to viral infection or TLR3 agonist treatment. Targeted depletion of CARINH or its mouse ortholog Carinh in

SUBMITTER: Cyr Y 

PROVIDER: S-EPMC11707381 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature