Differences in association between hypoalbuminaemia and mortality among younger versus older patients on haemodialysis.

ABSTRACT:

Background

Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum albumin <4.0 g/dl. This study explores whether age might affect serum albumin levels and its association with mortality in haemodialysis patients.

Methods

COSMOS (Current Management of Secondary Hyperparathyroidism: a Multicentre Observational Study) is a prospective, open-cohort, observational study of haemodialysis patients followed for 3 years. Binary logistic and linear regression were used to analyse the association between age and hypoalbuminaemia or serum albumin (continuous). Cox proportional hazard multivariate regression was used to examine the relationship

SUBMITTER: Sanz-Garcia C 

PROVIDER: S-EPMC11707383 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature