Interlinking pathways: a narrative review on the role of IL-6 in cancer and atherosclerosis.

ABSTRACT:

Background and objective

Interleukin-6 (IL-6) plays multifaceted roles in cancer and atherosclerosis. Initially recognized for its role in immune response and inflammation, IL-6 promotes tumor progression via the JAK-STAT and MAP kinase pathways and is associated with poor cancer prognoses. In atherosclerosis, IL-6 contributes to endothelial dysfunction and plaque formation. This review highlights the shared inflammatory mechanisms of IL-6 in both diseases and explores the regulatory dynamics of IL-6 signaling, including gene polymorphisms and epigenetic modifications.

Methods

Google Scholar, Scopus, and PubMed were searched for English-language articles on IL-6 and those reporting shared pathogenic mechanisms of IL-6 in cancer and atherosclerosis from their inception throug

SUBMITTER: Cau R 

PROVIDER: S-EPMC11707487 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature