CSP7 Protects Alveolar Epithelial Cells by Targeting <i>p53</i>-Fibrinolytic Pathways During Lung Injuries.

ABSTRACT: Impaired alveolar epithelial regeneration in patients with idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) is attributed to telomere dysfunction in type II alveolar epithelial cells (A₂Cs). Genetic susceptibility, aging, and toxicant exposures, including tobacco smoke (TS), contribute to telomere dysfunction in A₂Cs. Here we investigated whether improvement of telomere function plays a role in CSP7-mediated protection of A₂Cs against ongoing senescence and apoptosis during bleomycin (BLM)-induced pulmonary fibrosis (PF) as well as alveolar injury caused by chronic TS exposure. We found a significant telomere shortening in A₂Cs isolated from IPF and COPD lungs in line with other studies. These cells showed incr

SUBMITTER: Puthusseri B 

PROVIDER: S-EPMC11707667 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature