Sex-biased Regulation of Extracellular Matrix Genes in COPD.

ABSTRACT: Compared to men, women often develop COPD at an earlier age with worse respiratory symptoms despite lower smoking exposure. However, most preventive, and therapeutic strategies ignore biological sex differences in COPD. Our goal was to better understand sex-specific gene regulatory processes in lung tissue and the molecular basis for sex differences in COPD onset and severity. We analyzed lung tissue gene expression and DNA methylation data from 747 individuals in the Lung Tissue Research Consortium (LTRC), and 85 individuals in an independent dataset. We identified sex differences in COPD-associated gene regulation using gene regulatory networks. We used linear regression to test for sex-biased associations of methylation with lung function, emphysema, smoking, and age. Analyzing gene reg

SUBMITTER: Lopes-Ramos CM 

PROVIDER: S-EPMC11707671 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature