Tracing the paths of modular evolution by quantifying rearrangement events of protein domains.

ABSTRACT:

Background

Protein evolution is central to molecular adaptation and largely characterized by modular rearrangements of domains, the evolutionary and structural building blocks of proteins. Genetic events underlying protein rearrangements are relatively rare compared to changes of amino-acids. Therefore, these events can be used to characterize and reconstruct major events of molecular adaptation by comparing large data sets of proteomes.

Results

Here we determine, at unprecedented completeness, the rates of fusion, fission, emergence and loss of domains in five eukaryotic clades (monocots, eudicots, fungi, insects, vertebrates). By characterizing rearrangements that were previously considered "ambiguous" or "complex" we raise the fraction of resolved rearrangement events fro

SUBMITTER: Coban A 

PROVIDER: S-EPMC11707847 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature