Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005-2018.

ABSTRACT:

Background

The relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain.

Methods

This study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC analysis, subgroup and sensitivity analyses were also used.

Results

A total of 2442 adults with depression were included in the final analysis(average age: 46.51 ± 0.44 years). During a median follow-up of 89 months, there were 302 all-cause deaths and 74 cardiovascular deaths. The

SUBMITTER: Yu X 

PROVIDER: S-EPMC11707943 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature