Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC.

ABSTRACT:

Purpose

Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor progression and weaken drug sensitivity or facilitate tumor growth and drive therapeutic resistance. This study explores whether targeting TAMs can suppress the progression of head and neck squamous cell carcinoma (HNSCC) and improve the efficacy of chemotherapy.

Methods

Bioinformatics analyses were performed to evaluate TAMs infiltration levels in HNSCC tumor tissues and examine their associations with patients' clinicopathological characteristics and prognosis. Flow cytometry was utilized to measure the expression of key macrophage markers and assess apoptosi

SUBMITTER: Chen K 

PROVIDER: S-EPMC11707955 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature